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本文报道用850只雄性Wistar大鼠,腹腔注射不同强度的~(131)I,~(132)I,~(125)I后观察二年的结果。当~(131)I甲状腺吸收剂量为7.8GY时,甲状腺恶性肿瘤的发生率为45.8％,注入强度过大时,还可引起肺、软组织的肿瘤及肾脏、免疫器官的损伤。~(132)I和~(125)I都显示有最适致癌剂量范围及最适致癌剂量,当剂量降到某一数值时,可能存在一个不致癌剂量的实际下限值。~(131)I主要诱发甲状腺乳头状腺癌和混合癌,~(132)I主要为滤泡性腺癌和未分化癌,~(125)I主要为滤泡性腺癌和髓样癌。本文还讨论了甲状腺不同组织学类型癌细胞DNA定量细胞化学测定结果,认为,如参考血清中T_4降低,TSH升高,CIC升高等变化,它们对甲状腺癌的早期诊断可能是有帮助的。
In this paper, the results of two years were observed in 850 male Wistar rats after intraperitoneal injection of 131I, 132I, and 125I with different intensities. When ~(131)I thyroid absorbed dose was 7.8GY, the incidence of thyroid malignancy was 45.8%. When the injection intensity was too high, lung and soft tissue tumors, kidney and immune organs could also be damaged. Both ~(132)I and ~(125)I show the most suitable carcinogenic dose range and optimal carcinogenic dose. When the dose is reduced to a certain value, there may be a practical lower limit of non-carcinogenic dose. ~(131)I mainly induces thyroid papillary adenocarcinoma and mixed carcinoma, ~(132)I mainly follicular adenocarcinoma and undifferentiated carcinoma, ~(125)I mainly follicular adenocarcinoma and medullary carcinoma. This article also discusses the results of quantitative cytochemistry of cancer cell DNA in different histological types of thyroid glands. It is believed that if the reference serum is reduced in T4, TSH is elevated, and CIC is elevated, they may be helpful in the early diagnosis of thyroid cancer.