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目的观察复方血栓通胶囊对急性脑梗死患者血液流变学及血清神经元特异性烯醇化酶(NSE)、胰岛素样生长因-1(IGF-1)的影响。方法选取医院收治的急性脑梗死患者52例,按入院顺序随机分为对照组和观察组,每组26例。对照组给予抗凝、溶栓等常规治疗,观察组在常规治疗的基础上加用复方血栓通胶囊治疗,共治疗4周。治疗前后分别检测2组血液流变学指标及血清NSE、IGF-1水平。结果治疗4周后,2组血液流变学指标均较治疗前明显降低,且观察组治疗后血液流变学指标较对照组下降明显(P<0.01或P<0.05);2组血清NSE水平均较治疗前明显降低,而血清IGF-1水平较治疗前则明显升高(P<0.01或P<0.05);观察组治疗后血清NSE水平较对照组下降明显,血清IGF-1水平较对照组则明显升高(P<0.05)。结论复方血栓通胶囊可明显改善急性脑梗死患者血液流变学,降低血清NSE水平,提高血清IGF-1水平,具有保护脑神经功能的作用。
Objective To observe the effect of Fufang Xueshantong Capsule on the hemorheology, serum level of neuron specific enolase (NSE) and insulin-like growth factor-1 (IGF-1) in patients with acute cerebral infarction. Methods Fifty-two patients with acute cerebral infarction admitted to hospital were randomly divided into control group and observation group according to admission order, with 26 cases in each group. Control group given anticoagulant, thrombolytic and other conventional treatment, the observation group on the basis of conventional treatment plus compound Xueshuantong capsule treatment for a total of 4 weeks. Before and after treatment, 2 indexes of hemorheology and serum NSE and IGF-1 levels were detected respectively. Results After 4 weeks of treatment, the indexes of hemorheology in both groups were significantly lower than those before treatment, and the indexes of hemorrheology in the observation group decreased significantly (P <0.01 or P <0.05) after treatment. The level of serum NSE (P <0.01 or P <0.05). The level of serum NSE in the observation group decreased significantly compared with that in the control group, the level of serum IGF-1 in the observation group was significantly higher than that in the control group Group was significantly higher (P <0.05). Conclusion Compound Xueshuantong Capsule can obviously improve the hemorheology, reduce the level of serum NSE, increase the level of serum IGF-1 in the patients with acute cerebral infarction, and have the function of protecting brain function.