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现在已证实,与其他药物相比,双水杨酯可以更明显地降低2型糖尿病患者的血糖水平,且使用剂量更小。该研究共纳入286名2型糖尿病患者,随机分为3.5g/d双水杨酯组和安慰剂组。结果显示,HbA1c水平分别降低了0.24%,逊于降糖药、运动和饮食。在研究过程中,服用双水杨酯的患者时,减少了其他药物的使用剂量。而相比之下,安慰剂组却增加了其他糖尿病药物的使用剂量。双水杨酯还可以降低甘油三酯水平以及减少白细胞、中性粒细胞和淋巴细胞数量。与安慰剂组相比,接受双水杨酯治疗的患者体重增加了2.2kg,低密度脂蛋白胆固醇水平增加
It has now been demonstrated that salsalate reduces blood glucose levels more significantly in patients with type 2 diabetes than other drugs at a lower dosage. The study enrolled 286 patients with type 2 diabetes who were randomized to 3.5 g / d of salsalate and placebo. The results showed that HbA1c levels were reduced by 0.24%, worse than hypoglycemic agents, exercise and diet. During the study, patients taking salsalate reduced the dosage of other medications. In contrast, the placebo group increased the use of other diabetes drugs. Salsalate can also lower triglyceride levels and reduce the number of leucocytes, neutrophils and lymphocytes. Compared with placebo, patients treated with salsalate gained 2.2 kg of body weight and had an increase in low-density lipoprotein cholesterol