动物模型用于揭示许多人类疾病的机制,从实验室转化为病人的治疗,已有长远的历史。但对某些广泛应用的模型的局限性了解得越来越多。最近一篇系统分析研究比较小鼠和人对炎症的转录回应,加深了这种顾虑。“The lnflammation and Host Response to Injury,Large Scale Collaborative Research Program”用以前发表的和新近出版的小鼠 Animal models have long been known to reveal mechanisms of many human diseases that translate from the laboratory to the treatment of patients. However, the limitations of some widely used models are becoming more and more understood. A recent systematic review of studies comparing the transcriptional responses of mice and humans to inflammation has deepened this concern. “The lnflammation and Host Response to Injury, Large Scale Collaborative Research Program ” with previously published and newly published mice