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应用４批国产ＣＨＯ乙肝疫苗和２批进口酵母乙肝疫苗（Ｍｅｒｃｋ，Ａｍｇｅｎ），对３７０名小学生进行了２年（Ｔ２４）免疫效果观察。完成首针免疫后３月、（Ｔ３）７月、（Ｔ７）和１２月（Ｔ１２）时，各疫苗组的抗体阳转率均达９０％以上，其后开始下降。Ｔ７时国产ＣＨＯ疫苗抗体滴度与进口酵母疫苗无明显差异。Ｔ１２时Ａｍｇｅｎ疫苗组抗体ＧＭＴ显著高于其他各疫苗组。Ｔ２４时Ｍｅｒｃｋ苗组和一批ＣＨＯ苗组抗体滴度显著低于其他各疫苗组。结果表明国产ＣＨＯ疫苗抗体反应达到进口酵母疫苗水平。
Four batches of domestic CHO hepatitis B vaccine and two batches of imported yeast hepatitis B vaccine (Merck, Amgen) were used to observe the immune effect of 370 primary school students for two years (T24). The antibody positive rates in each vaccine group reached more than 90% at the end of the first immunization (T3, July, (T7) and December (T12)) and then decreased. T7 domestic CHO vaccine antibody titer and imported yeast vaccine no significant difference. At T12 Amgen vaccine antibody GMT was significantly higher than the other vaccine groups. Antibody titers of Merck seedlings and a group of CHO seedlings at T24 were significantly lower than those of other vaccine groups. The results showed that domestic CHO vaccine antibody response to the level of imported yeast vaccine.