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目的 :观察ＦＧＦ - 2对心肌细胞的 [Ｃａ2 +]ｉ是否有调节作用 ,并对ＦＧＦ - 2在心肌细胞促生长作用中的钙信号转导机制进行了初步的研究。方法 :选择狗胚心肌细胞系作为研究模型 ,观察 1、1 0、1 0 0和 1 0 0 0ｎｇ/ｍＬ重组ＦＧＦ - 2对细胞生长和细胞内钙离子的影响。细胞
AIM: To investigate whether FGF - 2 modulates [Ca2 +] i in cardiomyocytes and to investigate the mechanism of calcium signaling in FGF - 2 promoting cardiomyocyte growth. Methods: The dog embryo cardiomyocytes were selected as research model to observe the effects of recombinant FGF - 2 at concentrations of 1,1 0,1 0 0 and 1 0 0 0 ng / mL on cell growth and intracellular calcium. cell