近十多年来,在洋地黄作用的分子水平和药物动力学等研究上都有很大进展,对传统的“洋地黄化”概念提出了异议。目前各医院对心衰多已采用“小剂量维持疗法”,减少了洋地黄中毒率。为能更好地掌握这种疗法,特从药物动力学观点阐述于下。新概念的根据由于新技术的应用,得知强心甙在心肌与 In the recent ten years, great progress has been made in the studies on the molecular level and pharmacokinetics of digitalis and the objections to the traditional concept of “digitalis”. At present, hospitals have adopted “low-dose maintenance therapy” for heart failure, reducing the rate of digitalis intoxication. In order to better grasp this therapy, especially from the pharmacokinetic point of view elaborated below. According to the new concept of the application of new technologies, that cardiac glycosides in myocardium and