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目的 :测定升压灵注射液在家兔体内药代动力学参数。方法 :采用高效液相色谱法 ,以升压灵注射液中辛弗林为指标进行测定。流动相为甲醇 水 (5 5∶45 ,内含 0 .0 2M磷酸和 0 .2 %十二烷基硫酸钠 ) ,色谱柱YWG18(4 .6× 15 0mm) ,紫外检测波长为 2 75nm ,柱温 40°C ,流速 1ml/min。结果 :升压灵注射液静注后在兔体内呈二室模型分布 ,其药代动力学参数是Vc=5 3 .81ml/kg ,K12 =0 .2 7/min ,K2 1=0 .13/min ,K10 =0 .6 /min ,T1/ 2 α =0 .76min ,T1/ 2 β =8.2 3min ,α =0 .92min ,β =8.42× 10 -2 /min ,AUC =2 76 .36 μg/L·min ,Cl=32 .0 5ml/min。 结论 :临床上使用升压灵注射液时 ,可短期多次或缓慢静脉滴注给药
Objective : To determine the pharmacokinetic parameters of Sheng Ya Ling Injection in rabbits. Methods : High performance liquid chromatography was used for the determination of synephrine in Shengjiangling Injection. The mobile phase consisted of methanol water (5 5:45, containing 0.20 M phosphoric acid and 0.2% sodium lauryl sulfate), column YWG18 (4.6 × 150 mm), and UV detection wavelength of 2 75 nm. Column temperature 40 °C, flow rate 1ml/min. RESULTS: After Shengjiling injection was intravenously administered in rabbits, it was distributed in a two-compartment model. Its pharmacokinetic parameters were Vc=53.81ml/kg, K12=0.27/min, and K2=1=0.13. /min, K10 =0.6/min, T1/ 2 α =0.76min, T1/ 2 β=8.2 3min, α=0.92min, β=8.42×10 -2 /min, AUC=2 76 .36 Μg/L·min, Cl = 32.05 ml/min. Conclusion : It can be used for short-term multiple or slow intravenous drip