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目的探讨杀伤细胞免疫球蛋白样受体(KIR)基因多态性与白塞病(BD)发生是否存在关联。方法采用聚合酶链反应(PCR)／序列特异性引物(SSP)方法调查上海地区汉族95例白塞病患者和87名正常对照KIR基因位点的多态性。结果白塞病例组中KIR3DL1基因的频率(0．728)比对照组 (1．00)显著降低(RR=0．067,P=0．009);而其他各KIR基因频率与对照组相比差异无统计学意义。KIR单倍型频率、基因型频率与对照组相比差异也无统计学意义。结论上海地区汉族白塞病的发生可能与 KIR3DL1基因之间呈负相关。
Objective To investigate whether there is a relationship between killer cell immunoglobulin-like receptor (KIR) gene polymorphism and Behcet’s disease (BD). Methods Polymerase chain reaction (PCR) / sequence specific primer (SSP) method was used to investigate the polymorphism of KIR locus in 95 Han patients with Behcet’s disease in Shanghai and 87 normal controls. Results The frequency of KIR3DL1 gene in Behcet’s case group (0.728) was significantly lower than that in control group (1.00) (RR = 0.067, P = 0.009); while the frequencies of other KIR genes were significantly lower than those in control group The difference was not statistically significant. KIR haplotype frequency, genotype frequency compared with the control group, the difference was not statistically significant. Conclusions The occurrence of Behçet’s disease in Han Chinese may be negatively correlated with KIR3DL1 gene.