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目的:探索长期吸食甲基苯丙胺对机体免疫功能的影响。方法:采集51例长期吸食甲基苯丙胺患者(甲基苯丙胺组)的血样,检测其血常规、T淋巴细胞亚群(CD3~+、CD4~+、CD8~+、CD4~+/CD8~+)、B细胞(Bcell)、NK细胞(NK cell)、免疫球蛋白E(IgE)、免疫球蛋白G(IgG)、免疫球蛋白A(Ig A)、免疫球蛋白M(IgM)、补体C3、补体C4,并与53例健康体检者(正常对照组)进行比较。结果:甲基苯丙胺组CD3~+、CD4~+、CD4~+/CD8~+、B cell、NK cell、IgG、IgM、C3、C4较正常对照组降低,两者比较差异有统计学意义,两组之间CD8~+、IgE、Ig A差异无统计学意义。甲基苯丙胺组白细胞(WBC)、中性粒细胞(NEU)、中性粒细胞比率(NEU%)、淋巴细胞比率(LYM%)、血小板(PLT)较正常对照降低,差异具有统计学意义,两组淋巴细胞(LYM)、单核细胞(MON)、单核细胞比率(MON%)、红细胞(RBC)、血红蛋白(HGB)比较无统计学差异。结论:长期吸食甲基苯丙胺对免疫功能有不同程度的损害,甲基苯丙胺对机体免疫功能的抑制作用不仅作用于各种淋巴细胞,亦对某些血细胞有不同程度的抑制。
Objective: To explore the long-term absorption of methamphetamine on immune function. Methods: Totally 51 blood samples were collected from methamphetamine patients (methamphetamine group), and the levels of T lymphocyte subsets (CD3 +, CD4 +, CD8 +, CD4 + / CD8 + B cells, NK cells, IgE, IgG, IgA, IgM, complement C3 , Complement C4, and 53 healthy subjects (normal control group) were compared. Results: The levels of CD3 +, CD4 +, CD4 + / CD8 +, B cells, NK cells, IgG, IgM, C3 and C4 in methamphetamine group were lower than those in normal control group, There was no significant difference in CD8 ~ +, IgE and IgA between the two groups. The WBC, NEU, NEU%, LYM% and PLT in methamphetamine group were lower than those in normal control group, the difference was statistically significant, LYM, MON, MON%, RBC and HGB showed no significant difference between the two groups. Conclusion: Long-term inhalation of methamphetamine has different degrees of damage to immune function. The inhibitory effect of methamphetamine on the immune function not only affects various lymphocytes, but also inhibits some blood cells to some extent.