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目的比较国产和进口奥美拉唑注射液治疗消化性溃疡出血患者的临床疗效及药物成本—效果评价。方法将消化性溃疡出血患者100例随机分为2组,每组50例。试验组给予国产奥美拉唑治疗,对照组给予进口奥美拉唑治疗,比较2组疗效、不良反应及药物成本—效果评价。结果 2组治疗有效率、满意度及不良反应发生率比较差异无统计学意义(P>0.05),试验组成本—效果比低于对照组,差异有统计学意义(P<0.05)。结论针对消化性溃疡出血患者应用进口或国产奥美拉唑进行治疗,患者的临床治疗效果和安全性无差异,但两者的经济学成本相比,国产的药物明显优于进口药品。
Objective To compare the clinical efficacy and drug cost-effectiveness of domestic and imported omeprazole in patients with peptic ulcer bleeding. Methods 100 patients with peptic ulcer bleeding were randomly divided into two groups of 50 cases. The experimental group was given domestic omeprazole treatment, while the control group was treated with imported omeprazole. The curative effect, adverse reactions and drug cost-effectiveness were compared between the two groups. Results There was no significant difference in the treatment efficiency, satisfaction and incidence of adverse reactions between the two groups (P> 0.05). The cost-effectiveness ratio of the experimental group was lower than that of the control group (P <0.05). Conclusion For the patients with peptic ulcer hemorrhage treated with imported or domestic omeprazole, there is no difference in the clinical efficacy and safety of the patients. However, compared with the economic cost of the two drugs, domestic drugs are obviously better than imported drugs.