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该课题针对典型农业生物药物的功能与特点,以改善有效成分的溶解度、分散性、稳定性和靶向传输效率与控制释放功能,提高药效和减少残留污染为目标,采用纳米载体药物智能传输理论,系统地开展了生物农药、生物兽药和疫苗等纳米载药系统与剂型加工技术研究。该课题取得了一批具有国家先进水平的创新性研究成果:构建了纳米乳、纳米微囊、纳米微球、固体脂质纳米粒等具有靶向和控释功能的通用药物载体系统及其关键制备技术;研制了阿维菌素、井冈霉素、武夷菌素、醚菊酯等生物农药缓/控释剂、以及啶虫咪和氟虫腈等可原位降解剂,显著地改善了药物制剂的综合性能、安全性和环保性;研制了新型油佐剂、基
Aiming at the function and characteristic of typical agro-biopharmaceuticals, this project aims at improving the solubility, dispersibility, stability and efficiency of targeted delivery, controlling the release of active ingredients, improving efficacy and reducing residual contamination. Theory, systematically carried out biological pesticides, biological veterinary drugs and vaccines and other nano-drug delivery system and dosage form processing technology research. The subject has made a number of innovative research results with the national advanced level: a universal drug carrier system with targeting and controlled release functions such as nanoemulsion, nanocapsules, nanospheres and solid lipid nanoparticles has been built and its key Preparation of technology; developed avermectin, Jinggangmycin, Wuyiyu prime, etofenzine bio-pesticide slow / controlled release agent, and pyridine and fipronil and other in situ degradation agents, significantly improved the drug Preparation of the comprehensive performance, safety and environmental protection; developed a new oil adjuvant, based