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目的探讨益肾健脾祛风除湿汤联合贝那普利治疗慢性肾小球肾炎的临床疗效。方法选取保定市易县医院2014年6月—2015年12月收治的慢性肾小球肾炎患者86例。随机分为对照组42例与观察组44例。两组均给予常规治疗,西医予以盐酸贝那普利片,观察组在此基础上予认自拟益肾健脾祛风除湿汤加减治疗。比较两组患者临床疗效、尿蛋白定性、24 h尿蛋白定量、尿红细胞及不良反应发生情况。结果观察组患者临床疗效优于对照组(P<0.05)。治疗前两组患者尿蛋白定性、24h尿蛋白定量及尿红细胞比较,差异无计学意义(P>0.05);治疗后观察组患者尿蛋白定性优于对照组,24 h尿蛋白定量、尿红细胞少于对照组(P<0.05)。观察组患者不良反应发生率低于对照组(P<0.05)。结论益肾健脾祛风除湿汤联合贝那普利治疗慢性肾小球肾炎的临床疗效确切,可有效改善患者肾功能,安全性高。
Objective To investigate the clinical effects of Yishen Jianpi Qufeng Decoction combined with benazepril on chronic glomerulonephritis. Methods 86 patients with chronic glomerulonephritis admitted in Yixian County Hospital of Baoding from June 2014 to December 2015 were enrolled. Randomly divided into control group 42 cases and observation group 44 cases. Both groups were given conventional treatment, Western benazepril hydrochloride tablets, the observation group on the basis of premeditated Yishen Jianpi Qufeng Decoction therapy. The clinical efficacy, urinary protein qualitative, 24 h urinary protein quantitation, urine red blood cells and adverse reactions were compared between the two groups. Results The clinical efficacy of the observation group was better than that of the control group (P <0.05). Urine protein was qualitatively determined in the two groups before treatment, and 24-hour urinary protein and urinary erythrocytes were not statistically significant (P> 0.05). After treatment, the urinary protein in the observation group was better than that in the control group, Less than the control group (P <0.05). The incidence of adverse reactions in observation group was lower than that in control group (P <0.05). Conclusion Yishen Jianpi Qufeng Decoction combined with benazepril in the treatment of chronic glomerulonephritis clinical curative effect is exact, can effectively improve renal function in patients with high safety.