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目的观察拉克替醇对慢性病毒性肝炎患者肠道菌群及血内毒素水平的影响。方法60例慢性病毒性肝炎伴血内毒素升高的患者随机分为两组.对照组30例采用常规保肝降酶治疗.治疗组30例在常规治疗的基础上加用拉克替醇.观察两组患者治疗前及治疗3周后肠道菌群、血内毒素水平的变化。结果治疗组患者肠道内乳杆菌和双歧杆菌数量明显增加(P<0.01).产气荚膜梭菌显著降低(P<0.01).血内毒素水平显著降低(P<0.01)。结论拉克替醇能通过调节慢性病毒性肝炎患者肠道菌群,更有效降低血内毒素水平。
Objective To observe the effects of lactide on intestinal flora and blood endotoxin in patients with chronic viral hepatitis. Methods Sixty patients with chronic viral hepatitis with elevated serum endotoxins were randomly divided into two groups.The control group of 30 patients were treated with regular liver protection and enzyme-lowering therapy.30 cases in the treatment group were treated with lactid alcohol on the basis of routine treatment.Observed two The change of intestinal flora and blood endotoxin in group before treatment and after 3 weeks of treatment. Results The number of Lactobacillus and Bifidobacterium in the intestine was significantly increased in the treatment group (P <0.01), Clostridium perfringens was significantly decreased (P <0.01), and the level of endotoxin was significantly decreased (P <0.01). Conclusion Lactitol can lower the level of blood toxins effectively by regulating intestinal flora in patients with chronic viral hepatitis.