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目的观察利用结肠途径治疗机肠道清洗,配合中药“桑明合剂”保留灌肠治疗非酒精性脂肪肝(NAFLD)的临床疗效。方法将2015年5月~2016年3月期间在我院就诊的82例非酒精性脂肪肝患者随机分为治疗组40例与对照组各42例,予NAFLD健康教育,饮食及有氧运动指导。对照组口服水飞蓟宾胶囊,治疗组在对照组治疗基础上,予结肠途径治疗机肠道清洗+中药灌注。治疗60天后,比较两组临床症状变化,体重指数、脂肪肝程度、相关生化指标的差异。结果疗程结束后,治疗组患者胁痛、倦怠乏力、腹胀、口苦、大便不畅症状改善率均优于对照组(P<0.05或0.01);生化检测显示,治疗组患者TG、TC、UA指标显著改善,优于对照组(P<0.01),两组患者的肝功ALT、AST均较治疗前显著改善,但两组之间比较无显著差异;经治疗后,治疗组BMI指数、无创肝纤维化扫描肝脏脂肪变值均较治疗前有显著下降,改善程度优于对照组(P<0.01)。治疗组总有效率85%,对照组为42.8%,治疗组综合疗效优于对照组(P<0.01)。结论利用结肠途径治疗机肠道清洗后,再给予中药保留灌肠,治疗非酒精性脂肪肝效果明显,可改善症状,减轻肥胖,促进肝功及血脂好转,降低血尿酸水平。
Objective To observe the clinical efficacy of the colon route in the treatment of intestinal tract and the treatment of non-alcoholic fatty liver disease (NAFLD) with traditional Chinese medicine “Sanming Mixture” and retention enema. Methods 82 cases of non-alcoholic fatty liver disease treated in our hospital from May 2015 to March 2016 were randomly divided into treatment group (n = 40) and control group (n = 42). NAFLD health education, diet and aerobic exercise guidance . Control group oral silybin capsules, the treatment group in the control group on the basis of treatment, to the colon approach to treatment of intestinal clean + traditional Chinese medicine perfusion. After 60 days of treatment, the difference of clinical symptoms, body mass index, degree of fatty liver and the related biochemical indexes were compared. Results At the end of the course of treatment, the symptom improvement rate of hypochondriac pain, fatigue, bloating, mouth pain and stool in the treatment group were better than those in the control group (P <0.05 or 0.01). The biochemical tests showed that TG, TC, UA (P <0.01). ALT and AST of liver function in both groups were significantly improved compared with those before treatment, but there was no significant difference between the two groups; after treatment, the BMI index of the treatment group, non-invasive The hepatic steatosis value in liver fibrosis scan was significantly lower than that before treatment, and the improvement was better than that in control group (P <0.01). The total effective rate was 85% in the treatment group and 42.8% in the control group, and the comprehensive effect in the treatment group was better than that in the control group (P <0.01). Conclusions After the intestine was cleaned by colonic route, enema was preserved in the intestine and the treatment of non-alcoholic fatty liver was effective. Symptoms were relieved, obesity was alleviated, liver function and blood lipids were improved, and serum uric acid level was decreased.