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目的探讨应用微量泵治疗糖尿病酮症酸中毒的临床疗效。方法 2009年1月至2012年6月收治糖尿病酮症酸中毒患者60例,随机分为观察组及对照组,每组30例。观察组用微量泵治疗,微量泵以普通胰岛素0.1 U/(kg.h)持续静脉输注,依据每小时监测血糖调整输注速度,控制血糖在10 mmol/L左右;正常进食后停用微量泵,改用三餐前使用普通胰岛素和睡前使用中效胰岛素。对照组使用胰岛素泵加常规小剂量胰岛素静脉输注,未正常进食前胰岛素泵使用基础量,正常进食后停用胰岛素泵,改用三餐前使用普通胰岛素和睡前使用中效胰岛素。两组均常规补液消酮治疗。结果观察组与对照组血酮转阴时间、血糖达标时间、住院时间、低血糖发生率比较差异均无统计学意义(P>0.05)。结论微量泵与胰岛素泵在治疗糖尿病酮症酸中毒中疗效相当,值得在糖尿病酮症酸中毒治疗中推荐应用,特别是在无胰岛素泵的基层医院中使用。
Objective To investigate the clinical efficacy of using micropump in the treatment of diabetic ketoacidosis. Methods From January 2009 to June 2012, 60 patients with diabetic ketoacidosis were randomly divided into observation group and control group, with 30 cases in each group. The observation group was treated with the micropump. The micropump was continuously infused with normal insulin 0.1 U / (kg.h), and the infusion rate was adjusted according to the hourly monitoring of blood glucose to control the blood glucose at about 10 mmol / L. After normal eating, Pump, switch to regular meals before meals and before going to bed in the use of insulin. The control group used insulin pump plus conventional low-dose intravenous insulin infusion. The basal volume of insulin pump before normal eating was used. After the normal eating, the insulin pump was stopped. The regular insulin before meals and the middle-acting insulin before going to bed were used instead. Both groups were routine rehydration ketosis treatment. Results There were no significant differences in serum creatinine conversion time, blood glucose compliance time, hospitalization time and incidence of hypoglycemia between observation group and control group (P> 0.05). Conclusion Micropumps and insulin pumps have similar efficacy in the treatment of diabetic ketoacidosis and are worth recommending for the treatment of diabetic ketoacidosis, especially in primary hospitals without insulin pump.