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目的观察大蒜素对内皮细胞形态及内皮功能的影响．方法观察内皮细胞形态变化，同时检测培养液中超氧化物歧化酶（ＳＯＤ）活性、丙二醛（ＭＤＡ）及一氧化氮（ＮＯ）的含量.结果 一定剂量范围内（５，１０，２０，５０ｕｇ／ｍｌ）的大蒜素与内皮细胞共同孵育，能使培养液中的 ＮＯ含量、ＳＯＤ活性增高，ＭＤＡ含量下降（Ｐ＜０．０１或０．０５）．当大蒜素浓度为１００ｕｇ／ｍｌ时，上述作用反之，且光镜观察有细胞脱落现象．结论 大蒜素能促进内皮细胞 ＮＯ的合成，增加 ＳＯＤ的活性，降低 ＭＤＡ水平，对改善内皮细胞的功能状态，防治动脉粥样硬化（ＡＳ）起着积极的作用．
Objective To observe the effect of allicin on endothelial cell morphology and endothelial function. Methods Morphological changes of endothelial cells were observed. Simultaneously, superoxide dismutase (SOD) activity, malondialdehyde (MDA), and nitric oxide (NO) levels in the culture fluid were measured. Results within a certain dose range (5, 10, 20, 50 ug) Co-incubation of allicin with endothelial cells could increase the content of NO and SOD in the culture fluid and decrease the content of MDA (P<0.01 or 0.05). When the concentration of allicin 100ug/ml, the above effect is reversed, and light microscope observation of cell shedding phenomenon. Conclusion Allicin can promote the synthesis of NO in endothelial cells, increase the activity of SOD, decrease the level of MDA, and play an active role in improving the function of endothelial cells and preventing and treating atherosclerosis (AS).