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目的:了解肿瘤专科医院药品不良反应(ADR)发生的特点及规律。方法:对我院2010年1～12月收集并上报的623例ADR报告,分别从报告人、患者性别及年龄、引发ADR的药品种类、给药途径、ADR涉及器官或系统及临床表现等方面进行统计分析。结果:623例ADR报告中,40～50岁者ADR构成比最高,占31.14%:以抗肿瘤药居多,占52.49%;静脉滴注给药方式是引发ADR的主要给药途径,占63.56%;我院ADR最常见的临床表现为恶心呕吐以及骨髓抑制。结论:应加强化疗监护,综合考量患者身体状况,优化给药剂量,并重视ADR的监测工作,以减少ADR的发生。
Objective: To understand the characteristics and laws of adverse drug reaction (ADR) in cancer hospital. Methods: A total of 623 ADR cases collected and reported in our hospital from January to December in 2010 were analyzed in terms of the reporter, patient’s sex and age, the type of drug causing ADR, route of administration, organ or systemic and clinical manifestations of ADR conduct statistical analysis. Results: Among the 623 ADR cases, the ADR was the highest in 40-50 years old group, accounting for 31.14% of the total: 52.49% of them were anticancer drugs, and the main route of administration of ADR was 63.56% The most common clinical manifestations of ADR in our hospital were nausea, vomiting and myelosuppression. Conclusion: Chemotherapy care should be strengthened, comprehensive consideration of the patient’s physical condition, to optimize the dose, and pay attention to the monitoring of ADR in order to reduce the occurrence of ADR.