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目的观察食管癌根治性放疗后复发患者应用低剂量紫杉醇联合调强放疗治疗的效果及安全性。方法食管癌根治性放疗后复发患者44例,随机分为对照组21例和观察组23例,对照组给予调强适形放疗,观察组在调强适形放疗同时给予紫杉醇40mg/m2,第1、8、15、22、29、36天静脉滴注。治疗后1个月评估2组疗效,并比较2组不良反应发生情况。结果观察组临床缓解率(95.65%)明显高于对照组(71.43%)(P<0.05),2组不良反应发生率比较差异无统计学意义(P>0.05)。结论食管癌根治性放疗后复发患者应用低剂量紫杉醇联合调强放疗治疗可提高近期疗效,不良反应轻。
Objective To observe the efficacy and safety of low-dose paclitaxel combined with intensity-modulated radiation therapy in patients with recurrent esophageal cancer after radical radiotherapy. Methods Forty-four patients with recurrent esophageal cancer after radical radiotherapy were randomly divided into control group (n = 21) and observation group (n = 23). The control group was given intensity modulated conformal radiotherapy. The observation group received paclitaxel 40 mg / 1,8,15,22,29,36 days intravenous drip. One month after treatment, two groups of curative effect were evaluated, and the occurrence of adverse reactions in two groups were compared. Results The clinical remission rate (95.65%) in the observation group was significantly higher than that in the control group (71.43%) (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusions The treatment of esophageal cancer recurrence after radical radiotherapy with low-dose paclitaxel combined with intensity-modulated radiation therapy can improve the short-term efficacy of adverse reactions.