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目的 :观察国产两根型皮埋剂 Sino-implant及十一酸睾酮 (TU)针剂联合应用对中国男性垂体促性腺激素和睾酮水平的影响。方法 :共征集自愿对象 1 6名 ,前臂埋植 Sino-im-plant,每根含左旋 1 8-甲基炔诺酮 75mg,并于 3周后每月肌注针剂十一酸睾酮 (TU) ,(2 50 mg) ,共 3次。结果 :放置皮埋剂后血清中 FSH、L H水平有所下降。注射第 1针 TU后 ,FSH、L H水平进一步下降 ,于注射后 1周达到谷值 ,之后 FSH、L H水平又有所上升 ;注射第 2、3针 TU后 ,FSH、L H水平变化情况与第 1针时相似。此外 ,皮埋后对象血清睾酮水平也有所下降 ,注射第 1针 TU后 ,则睾酮水平升高 ,并于注射后 1周达峰值 ,之后睾酮水平又有所下降 ;注射第 2、3针 TU后血清睾酮水平变化情况与第 1针时相似。结论 :皮埋剂Sino-implant和 TU配伍应用可对垂体促性腺激素分泌产生协同抑制作用 ,从而使内源性睾酮水平下降 ;但注射 TU可补充睾酮 ,使之维持正常水平。故国产皮埋剂配伍 TU很有希望用于男性避孕
Objective: To observe the effect of Sino-implant and testosterone undecanoate (TU) on the levels of pituitary gonadotropin and testosterone in Chinese men. Methods: Totally 16 volunteers were enrolled in this study. Sino-im-plant was implanted in the forearm, each containing 75 mg of levonorgestrel 75 mg once daily for three weeks. The monthly intramuscular injection of testosterone undecanoate (TU) , (2 50 mg) for 3 times. Results: The levels of FSH and LH in the serum decreased after the skin burial agent was placed. After injection of the first needle of TU, the level of FSH and LH decreased further and reached the bottom one week after the injection, then the level of FSH and LH increased again. 1 pin similar. In addition, the level of serum testosterone decreased after the first injection of TU, but the level of testosterone increased at the first week after injection, and the testosterone level decreased after injection. The second and third needle TU Serum testosterone levels after the change is similar to the first one. Conclusion: The combination of Sino-implant and TU can inhibit the secretion of pituitary gonadotropin and thus reduce the level of endogenous testosterone. However, TU can be supplemented with testosterone to maintain its normal level. Therefore, the compatibility of domestic skin burial agent TU is promising for male contraception