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口腔毛状白斑(OHL)常发生于感染了人免疫缺陷 病毒(HIV)的患者。临床表现为不能除去的白色损害,其表面皱折或平坦,通常出现在舌侧缘。组织病理学上表现为上皮增生、过度不全角化、棘层细胞呈气球样变。DNA原位杂交,电镜和免疫组织化学证实上皮细胞内存在EB病毒。已有报道OHL发生在免疫抑制的HIV阴性的患者。本文首例报道白塞综合征患者伴OHL。
Oral hairy leukoplakia (OHL) often occurs in patients infected with human immunodeficiency virus (HIV). Clinically manifested as white lesions that can not be removed, the surface is crumpled or flattened and usually appears on the lingual margins. Histopathology showed epithelial hyperplasia, overcomplete keratosis, acanthosis cells were balloon-like changes. DNA in situ hybridization, electron microscopy and immunohistochemistry confirmed the presence of Epstein-Barr virus in epithelial cells. OHL has been reported in HIV-negative immunosuppressed patients. This is the first case report of patients with Behcet's syndrome with OHL.