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Ge-132[carboxyethylgermanium sesquioxide,O_3(GeCH_2CH_2COOH)_2]是一种有机锗化合物,最初由日本学者浅井一彦于1967年合成。其理化性质及化学结构已于1976年由Tsutsui M等阐明。药理 Ge-132主要是具有抗肿瘤和抗病毒作用。此外,尚具有增强内啡肽麻醉的作用以及对缺血的保护作用。 1.抗肿瘤作用 Kumano N曾观察Ge-132对C_(57)BL/6小鼠Lewis肺癌(3 LL)移植瘤及其肺部转移灶的影响。发现接种肿瘤后给予Ge-132100mg/kg连续7天抑瘤率可达49%。最佳
Ge-132 [carboxyethylgermanium sesquioxide, O_3 (GeCH_2CH_2COOH) _2] is an organogermanium compound originally synthesized by Japanese scholar Asai Iwasawa in 1967. Its physical and chemical properties and chemical structure have been elucidated in 1976 by Tsutsui M et al. Pharmacology Ge-132 is mainly anti-tumor and anti-virus. In addition, it also has the role of enhancing endorphin anesthesia and the protective effect on ischemia. 1. Antitumor effect Kumano N had observed the effects of Ge-132 on Lewis lung carcinoma (3 LL) xenografts and its lung metastases in C57BL / 6 mice. It was found that Ge-132100mg / kg was given for 49 days in 7 consecutive days after tumor inoculation. optimal