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目的:初步探讨稳定型冠心病(CAD)患者动静脉血浆B型利钠肽(BNP)浓度的变化及其与冠脉病变的关系。方法:所有患者均经心脏超声和冠脉造影检查,应用化学发光法测定43例经冠脉造影(CAG)证实的稳定型CAD、22例急性冠脉综合征(ACS)和22例CAG正常患者动、静脉(冠状动脉窦和贵要静脉)BNP浓度,收集临床资料,进行统计分析和比较。结果:(1)各组动、静脉血浆BNP浓度无显著差异(P>0.05);(2)ACS组动静脉血浆BNP浓度均显著高于CAG正常组和稳定型CAD组(P<0.01);(3)稳定型CAD组的动脉血浆BNP浓度显著高于CAG正常组(P<0.05),但静脉血浆浓度比较无显著差异(P>0.05);(4)冠脉病变狭窄程度越严重,BNP浓度越高(P<0.05)。结论:血浆BNP浓度可能是反映稳定型CAD患者冠脉病变严重程度的一个预测因子。
Objective: To investigate the changes of arterial-venous plasma B-type natriuretic peptide (BNP) in patients with stable coronary heart disease (CAD) and its relationship with coronary artery disease. Methods: All patients underwent echocardiography and coronary angiography. Chemiluminescence was used to detect 43 stable CAD patients confirmed by coronary angiography (CAG), 22 acute coronary syndromes (ACS) and 22 normal CAG patients The arterial and venous (coronary sinus and VIP) BNP concentration, clinical data were collected for statistical analysis and comparison. Results: (1) There was no significant difference in BNP concentration between arterial and venous blood in each group (P> 0.05). (2) Plasma BNP concentration in ACS group was significantly higher than that in CAG normal group and stable CAD group (P <0.01). (3) Plasma BNP concentration in stable CAD group was significantly higher than that in CAG normal group (P <0.05), but there was no significant difference in venous plasma concentration (P> 0.05); (4) The higher concentration (P <0.05). Conclusions: Plasma BNP concentration may be a predictor of the severity of coronary lesions in patients with stable CAD.