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亲环素A(cyclophilin A,CypA)是一种分子质量为20 kD的伴侣蛋白质,属亲免素家族成员,具有肽基-脯氨酸顺/反异构酶活性,CypA有许多重要的生物学功能,如辅助蛋白折叠、介导细胞间信号转导、参与氧化应激和炎症应答。近年来,关于CypA的研究主要集中在CypA与一些病毒感染性疾病的发生发展关系上,特别是与病毒性肝炎(HBV/HCV)、获得性免疫缺陷综合征(AIDS)和甲型H1N1禽流感(influenza virus A)等。进一步研究CypA在病毒感染性疾病中的作用与分子机制具有重要意义。
Cyclophilin A (CypA) is a chaperone protein with a molecular mass of 20 kD. It belongs to a member of the immunophilin family and possesses peptidyl-proline cis / trans isomerase activity. CypA has many important biological Learning functions, such as protein folding assist, mediate signal transduction between cells, participate in oxidative stress and inflammatory response. In recent years, the research on CypA mainly focuses on the relationship between CypA and some viral infectious diseases, especially with the viral hepatitis (HBV / HCV), Acquired Immune Deficiency Syndrome (AIDS) and the Influenza A (H1N1) (influenza virus A) and so on. Further study of the role of CypA in viral infectious diseases and molecular mechanisms is of great significance.