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通过结构改造并结合活性基团的拼接合成了11个未见文献报道的新型2-(2’-取代亚肼基)-1,3-二硫杂环戊烷类化合物,所有的目标物的结构都经HNMR,MS,IR和元素分析证实,选择了其中5个化合物对7种细菌进行了抑菌活性1测试,并与市售农药20%三环唑、70%威尔达甲托的抑菌活性进行对比,发现它们比市售农药有更为广泛的杀菌谱,对照农药只对金黄色葡萄球菌有良好的抑菌作用而这些化合物则对所选择的七个菌种均有良好的抑菌作用.其中化合物2-(对氟苯氧乙酰亚肼基)-1,3-二硫杂环戊烷(4c)的杀菌谱很广,它对金色葡萄球菌、大肠杆菌、白色念珠菌的抑杀活性都很好.
Eleven novel 2- (2’-substituted hydrazono) -1,3-dithiolane compounds were synthesized by structural modification combined with active group splicing. All of the target The structures were confirmed by HNMR, MS, IR and elemental analysis. Five of the five compounds were tested for antibacterial activity against seven kinds of bacteria and tested with the commercially available pesticides 20% tricyclazole, 70% Antibacterial activity were compared and found that they have more widely than the commercially available pesticides bactericidal spectrum, the control of pesticides only has a good antibacterial effect against Staphylococcus aureus and these compounds are selected for the seven species have good Bacteriostasis in which the compound 2- (p-fluorophenoxyhydrazono) -1,3-dithiolane (4c) bactericidal spectrum is very broad, it Staphylococcus aureus, Escherichia coli, Candida albicans Antibacterial activity are good.