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目的:探讨环胍氨酸肽抗体(CCP)、抗核抗体(ANA)在临床的应用价值及其相关性。方法:用间接免疫荧光法(IFA)检测50例类风湿患者标本中的ANA。用EL ISA方法检测CCP,比较ANA与CCP的相关性。结果:(1)CCP阳性类风湿患者ANA的阳性率为94%,ANA阳性病例都是颗粒型和(或)均质型;(2)CCP浓度分布与ANA阳性率的相关性的研究,用t检验分析P>0.05,表明各个CCP浓度组的ANA阳性率无差异。结论:大多数CCP阳性类风湿患者标本ANA阳性,ANA可作为RA辅助诊断指标。
Objective: To investigate the clinical value of cyclic citrullinated peptide antibody (CCP) and antinuclear antibody (ANA) in clinical application. Methods: ANA in 50 rheumatoid patients was detected by indirect immunofluorescence (IFA). The CCP was tested by EL ISA, and the correlation between ANA and CCP was compared. Results: (1) The positive rate of ANA in patients with CCP-positive rheumatoid was 94%, and the positive cases of ANA were granular and / or homogeneous. (2) The correlation between the concentration of CCP and the positive rate of ANA was t test analysis of P> 0.05, indicating that the concentration of ANA in each concentration group no difference. Conclusion: The majority of CCP-positive patients with rheumatoid ANA-positive specimens, ANA can be used as a diagnostic indicator of RA.