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目的比较原发性卵巢功能不全(primary ovarian insufficiency,POI)病人、绝经期妇女及正常体检女性的性激素、糖脂代谢及其他生物化学指标之间的差异,以期提高对POI病人健康状况的关注程度。方法纳入108例POI病人、114名绝经期女性、63例正常体检女性,分别测量其性激素、糖脂代谢、其他生物化学指标(相关检测试剂盒的批间误差、批内误差控制在3%~5%)。结果 3组之间体质量指数(body mass index,BMI)差异无统计学意义(P>0.05),卵泡刺激素(follicle stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、雌二醇(estradiol,E2)两两比较差异均有统计学意义(P<0.05)。总胆固醇(total cholesterol,TC)、空腹胰岛素[fasting insulin,FINS]、胰岛素抵抗指数(homeostasis model assessment of insulin resistance,HOMA-IR)POI组与绝经组的测量值均明显大于对照组(P<0.05)、高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)和睾酮(testosterone,T)浓度明显低于对照组(P<0.05)。结论本研究中POI病人的TC、FINS、HOMA-IR、HDL-C已经达到绝经期女性水平(P<0.05),长期发展可能影响病人的生活质量,临床医生应及早对POI病人进行干预与治疗。
Objective To compare the differences of sex hormones, glucose and lipid metabolism and other biochemical parameters among women with primary ovarian insufficiency (POI), menopausal women and normal physical examination in order to improve the degree of attention to the health of POI patients . Methods A total of 108 POI patients, 114 menopausal women and 63 normal women were enrolled in the study. The levels of sex hormones, glucose and lipids, and other biochemical parameters were measured. The error of the correlation kit was between 3% 5%). Results There was no significant difference in body mass index (BMI) between the three groups (P> 0.05), follicle stimulating hormone (FSH), luteinizing hormone (LH) (estradiol, E2) between the two groups were statistically significant differences (P <0.05). The measured values of total cholesterol (TC), fasting insulin (FINS) and homeostasis model assessment of insulin resistance (HOMA-IR) in POI group and menopause group were significantly higher than those in control group (P <0.05 ), High density lipoprotein-cholesterol (HDL-C) and testosterone (T) were significantly lower than those of the control group (P <0.05). Conclusions In this study, the levels of TC, FINS, HOMA-IR and HDL-C in POI patients have reached the level of postmenopausal women (P <0.05). Long-term development may affect the quality of life of patients. Clinicians should take early intervention and treatment of POI patients .