患者,男,47岁。1997年6月1日于双下肢皮肤出现丘疹,以小腿内侧为甚,呈鲜红色,初为针尖或米粒大小,为对称散在分布,无搔痒及疼痛,无发热及关节痛,2日后皮疹向周围扩延增大,并有融合倾向,红斑中央色泽变深,有小血疱或聚集性水疱形成,曾在当地医院外敷中药,无好转。1周后又出现脐周隐痛,伴恶心、干呕,有腹泻,为黑色软便,每日 Patient, male, 47 years old. On June 1, 1997, pimples appeared on the skin of both lower extremities, with a bright red color on the medial side of the lower leg. The size of the needle tip or rice grain was initially sparsely distributed with no itch and pain, no fever and joint pain. After 2 days, Around the expansion increases, and the tendency to fusion, erythema become darker in the center, a small blood vesse or aggregated blisters formed, in the local hospital with traditional Chinese medicine, no improvement. 1 week later appeared umbilical pain, nausea, retching, diarrhea, black stool, daily