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目的探讨不同浸润方式舌鳞状细胞癌淋巴管生成的特点及临床意义。方法 参照Anneroth等描述的肿瘤浸润方式对41例舌鳞状细胞癌进行分型,应用免疫组化法,以D2-40标记淋巴管,计数淋巴管密度(lymphatic vessel density,LVD)。结果不同浸润方式的舌鳞状细胞癌D2-40的表达不同,浸润方式为Ⅲ、Ⅳ型的舌鳞状细胞癌,淋巴管密度(LVD)显著高于Ⅰ、Ⅱ型(P<0.05),且临床易出现淋巴结转移。结论Ⅲ、Ⅳ型浸润方式的舌鳞状细胞癌恶性程度高,可能具有较强的诱导淋巴管生成的能力。
Objective To investigate the characteristics and clinical significance of lymphangiogenesis in tongue squamous cell carcinoma with different infiltration patterns. Methods 41 cases of tongue squamous cell carcinoma were classified according to the way of tumor infiltration described by Anneroth et al. Lymphatic vessel density (LVD) was counted by D2-40 labeling of lymphatic vessels by immunohistochemistry. Results The expression of D2-40 was different in different invasive ways of tongue squamous cell carcinoma. The infiltrative mode was type Ⅲ and type Ⅳ tongue squamous cell carcinoma, the LVD was significantly higher than that of type Ⅰ and type Ⅱ (P <0.05) And clinically prone to lymph node metastasis. Conclusion Ⅲ and Ⅳ infiltration of tongue squamous cell carcinoma of the high degree of malignancy, may have a strong ability to induce lymphangiogenesis.