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目的:探讨酪酸梭菌二联活菌散治疗小儿抗生素相关性腹泻的疗效。方法:选取2011年2月至2012年2月在我院住院治疗的抗生素相关性腹泻患儿120例,随机分治疗组65例和对照组55例,对照组给予饮食调节,纠正水、电解质、酸碱平衡紊乱等常规治疗,治疗组在常规治疗的基础上给予酪酸梭菌二联活菌散口服,比较两组治疗有效率、大便性状改变时间、腹泻持续时间和腹泻次数减少时间。结果:酪酸梭菌二联活菌散可显著提高患儿抗生素相关性腹泻治疗的有效率(χ2=14.16,P<0.05),缩短大便性状改变时间(t=2.49,P<0.05)、腹泻持续时间(t=2.62,P<0.05)及腹泻次数减少时间(t=2.21,P<0.05),与对照组比较差异均有统计学意义。结论:酪酸梭菌二联活菌散治疗小儿抗生素相关性腹泻疗效显著。
Objective: To investigate the curative effect of Clostridium butyricum inactivated antibiotic-associated diarrhea in children. Methods: 120 cases of antibiotic-associated diarrhea hospitalized in our hospital from February 2011 to February 2012 were randomly divided into treatment group (n = 65) and control group (n = 55). The control group was given diet adjustment to correct water, electrolyte, Acid-base balance disorders and other conventional treatment, the treatment group given routine treatment of Clostridium butyricum oral combined oral administration, the two groups were treated with efficiency, stool traits change time, duration of diarrhea and diarrhea reduce the time. Results: Clostridium butyricum inactivated antibiotics could significantly improve the antibiotic-associated diarrhea treatment efficiency (χ2 = 14.16, P <0.05), shortened stool change time (t = 2.49, P <0.05) Time (t = 2.62, P <0.05) and diarrhea frequency (t = 2.21, P <0.05). There were significant differences between the two groups. Conclusion: Clostridium butyricum two live bacteria powder treatment of pediatric antibiotic-related diarrhea effect is significant.