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自从Brunton在本世纪报告亚硝酸异戊酯可缓解心绞痛以来,有关硝酸酯缓解心脏缺血性疼痛的效能尚未受到质疑.虽然硝酸酯至今仍是所有抗心绞痛新药的参比药物,对其有益作用的确切机理尚不肯定.近年,大致有三种假设.硝酸酯是冠状血管扩张剂,通过降低冠状血管阻力而增加冠状血流量.此一观点显然是不充分的.如果冠状血管扩张剂是指使流向正常,非缺血心肌的冠状动脉血流量增加的药物,则治疗剂量硝酸甘油是一种极
The effectiveness of nitrates in relieving cardiac ischemic pain has not been questioned since Brunton reported isoinamyl nitrite for relief of angina in this century. Although nitrates are by far the reference drug for all new anti-angina drugs, The exact mechanism is not yet sure. In recent years, there are roughly three hypotheses .Nitrate is a coronary vasodilator, by reducing coronary vascular resistance and increase coronary blood flow .This view is clearly inadequate.If coronary vasodilator refers to the flow Normal, non-ischemic myocardial coronary blood flow increased drug, the treatment dose of nitroglycerin is a kind of pole