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目的研究presepsin对急性盆腔炎的诊断和疗效评估价值。方法检测2014年6月-2016年5月来医院就诊的116例急性盆腔炎患者和60例健康体检者的presepsin、降钙素原水平。采用ROC曲线法评价presepsin对急性盆腔炎的诊断价值,并与PCT进行比较。根据疗效分为痊愈组、有效组、无效组,并对各组患者治疗前后的血浆presepsin、降钙素原水平进行比较。结果急性盆腔炎患者组presepsin、PCT浓度均高于对照组,差异有统计学意义(P<0.01)。presepsin的诊断界值为317 pg/ml,敏感度和特异度分别为69.2%和83.6%;PCT的诊断界值为0.25 ng/ml,敏感度和特异度分别为55.8%和75.5%,presepsin诊断急性盆腔炎的敏感度和特异度均高于PCT。痊愈组、有效组治疗后presepsin、PCT水平低于治疗前,差异均有统计学意义(P<0.05);无效组治疗后presepsin、PCT水平与治疗前比较,差异均无统计学意义(P>0.05)。结论 presepsin可作为急性盆腔炎的诊断生物标志物,其诊断价值与PCT相当,对急性盆腔炎的疗效评估具有潜在的临床价值。
Objective To study the value of presepsin in the diagnosis and treatment of acute pelvic inflammatory disease. Methods The levels of presepsin and procalcitonin in 116 patients with acute pelvic inflammatory disease and 60 healthy controls from June 2014 to May 2016 were measured. The diagnostic value of presepsin in acute pelvic inflammatory disease was evaluated by ROC curve method and compared with PCT. According to the curative effect, the patients were divided into recovery group, effective group and ineffective group. The levels of plasma presepsin and procalcitonin were compared before and after treatment. Results The concentrations of presepsin and PCT in patients with acute pelvic inflammatory disease were significantly higher than those in control group (P <0.01). The diagnostic cutoff value of presepsin was 317 pg / ml and the sensitivity and specificity were 69.2% and 83.6% respectively. The diagnostic cutoff value of PCT was 0.25 ng / ml and the sensitivity and specificity were 55.8% and 75.5% respectively. Presepsin diagnosis The sensitivity and specificity of acute pelvic inflammatory disease were higher than PCT. In the recovery group, the levels of presepsin and PCT in the effective group were lower than those before treatment (P <0.05), while the levels of presepsin and PCT in the invalid group were not significantly different from those before treatment (P> 0.05). Conclusion Presepsin can be used as a diagnostic biomarker for acute pelvic inflammatory disease. Its diagnostic value is comparable to that of PCT, and it has potential clinical value in evaluating the therapeutic effect of acute pelvic inflammatory disease.