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对16例胃癌患者和16例正常健康人的外周血淋巴细胞的微核、姊妹染色单体互换(SCE)以及染色体畸变进行了观察和比较。结果发现,正常健康人和患者的微核率分别为0.053％和0.197％;SCE频率均值为6.34±0.46和10.17±1.24;染色体畸变率分别为2.71％和6.67％。胃癌患者均高于正常健康人,且有显著性差异。表明胃癌的发生与染色体不稳定性及DNA修复能力有关。
The micronucleus, sister chromatid exchange (SCE) and chromosomal aberrations in peripheral blood lymphocytes from 16 patients with gastric cancer and 16 normal healthy people were observed and compared. The results showed that the frequencies of micronuclei in healthy individuals and patients were 0.053% and 0.197%, respectively; the mean frequencies of SCE were 6.34±0.46 and 10.17±1.24; the chromosome aberration rates were 2.71% and 6.67%, respectively. Patients with gastric cancer were all higher than normal healthy people and there were significant differences. It indicates that the occurrence of gastric cancer is related to chromosomal instability and DNA repair ability.