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目的探讨血清游离轻链(s FLC)在多发性骨髓瘤(MM)诊断和疗效评估中的应用价值。方法选取中国人民解放军武汉总医院2016年1月—2017年1月收治的初诊MM患者400例为观察组,另选择本院同期健康体检者200例为对照组及免疫球蛋白G(Ig G)型MM患者200例。通过免疫散射比浊法观察患者化疗后s FLC水平。结果 400例观察组患者中κ型MM 216例,λ型MM 184例。观察组患者s FLC水平高于对照组(P<0.05)。不同疗效患者s FLC-κ、s FLC-λ水平比较,差异有统计学意义(P<0.05)。结论 s FLC在MM诊断中具有一定参考价值,其变化水平与病情控制相关,可作为MM疗效的评价指标。
Objective To investigate the value of serum free light chain (s FLC) in the diagnosis and evaluation of multiple myeloma (MM). Methods 400 cases of newly diagnosed MM patients admitted to Wuhan General Hospital of Chinese PLA from January 2016 to January 2017 were selected as the observation group. Another 200 cases of healthy subjects in the same period were selected as the control group and immunoglobulin G (Ig G) Type MM patients 200 cases. Immunostaining turbidimetry was used to observe the level of s FLC after chemotherapy. Results Among the 400 observation group, 216 were κ-type MM and 184 were λ-type MM. The level of sFLC in observation group was higher than that in control group (P <0.05). There was significant difference in s FLC-κ, s FLC-λ levels between different curative effects (P <0.05). Conclusion s FLC has certain reference value in the diagnosis of MM, and its level of change is related to disease control, which can be used as an evaluation index of MM efficacy.