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新生儿的药物剂量较难掌握,尤其是出生后一周内的早产儿、极低出生体重儿,个体差异颇大,给药常需个别化。欧美很多医学中心常以药物血浓度的高低来指导给药间隔时间及剂量。国内有些单位也开展了地高辛、苯巴比妥、庆大霉素等血浓度的测定工作,但还很难在短时间内推广采用。在新生儿用药不但与成人不同,而且也不同于其它年龄的小儿,这主要由于其药物代谢动力学有很多特点。首先,胎龄、日龄越小、体重越轻新生儿的肝、肾功能越不成
Neonatal drug dosage is more difficult to grasp, especially in the week after birth, premature children, very low birth weight children, individuals vary widely, often require individualized administration. Many medical centers in Europe and the United States often use drug blood concentration to guide the interval and dose. Some domestic units also carried out the determination of digoxin, phenobarbital, gentamicin and other blood concentrations, but still difficult to promote the use of a short time. In neonatal medication is not only different from adults, but also different from other age children, mainly due to its pharmacokinetics has many characteristics. First of all, gestational age, the smaller the age, the lighter the newborn liver and kidney function less