精氨酸酶在尿素循环中催化精氨酸水解成鸟氨酸和尿素,被二价阳离子(Mn)激活的精氨酸酶主要存在于人的肝、肾和红细胞中。恶性贫血、地中海贫血和肝脏疾病中血清精氨酸酶活力可增高,Chmielnicka报告在接触铅而引起肝损的患者中发现血清精氨酸酶活力增高,但对铅影响红细胞精氨酸酶活力未作充分讨论。 本文用半自动方法使用干血斑测定红细胞精氨酸酶活力,利用Zielhuis等介绍的流行病毒理学的生物试验的有效性概念,研究了铅指标试验中的灵敏度(SE)、异特性(Sp)、和有效性(V),发现血铅的基值为40μg/100g Arginase catalyzes the hydrolysis of arginine to either ornithine and urea in the urea cycle, and arginase activated by divalent cations (Mn) is found predominantly in human liver, kidney and red blood cells. Serum arginase activity is elevated in pernicious anemia, thalassemia, and liver disease, and Chmielnicka reports elevated serum arginase activity in patients exposed to lead-induced liver damage, but affects lead on erythrocyte arginase activity Make a full discussion. The semi-automatic method was used to determine erythrocyte arginase activity using dry blood spot. The concept of validity of the biological test of epidemiological toxicology introduced by Zielhuis et al was used to study the sensitivity, specificity, And effectiveness (V), the base value of blood lead was found to be 40 μg / 100 g