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目的基于分子自组装原理,以医用聚乙二醇(polyethylene glycol,PEG,Mn=2 000)与β-环糊精(beta-cyclodextrin,β-CD)形成新型囊泡,包合水溶性药物梓醇。方法通过透射电镜(TEM)、Zeta电位仪和激光粒度仪表征囊泡的形貌和结构。紫外可见分光光度计测定囊泡的药物包合率。结果载药囊泡制备成功,其粒径分布在110 nm左右,接近纳米囊泡级别;Zeta电位在-19 m V左右,说明囊泡稳定性较好。并且,粒径和Zeta电位均随囊泡浓度和p H值的改变呈相关趋势改变,为优化囊泡的制备提供了参考。囊泡的载药率在52%左右,载药率良好。结论该实验为水溶性药物的包合提供了参考。
OBJECTIVE Based on the principle of molecular self-assembly, a new vesicle was formed with polyethylene glycol (PEG, Mn = 2000) and β-cyclodextrin (β-CD) alcohol. Methods Morphology and structure of the vesicles were characterized by transmission electron microscopy (TEM), Zeta potential meter and laser particle sizer. UV-Vis spectrophotometer determination of vesicle drug inclusion rate. Results The drug-loaded vesicles were successfully prepared and their particle size distribution was about 110 nm, which was close to the level of nanofeatures. The Zeta potential was about -19 mV, indicating that the vesicles were stable. Moreover, both the particle size and Zeta potential changed with the change of vesicle concentration and p H value, which provided a reference for the optimization of vesicle preparation. Vesicle drug loading rate of 52%, drug loading rate is good. Conclusion This experiment provides a reference for inclusion of water-soluble drugs.