丙咪嗪作为三环抗抑郁剂广泛应用已有20多年。近来证实该药有抗心律失常的作用。本文报告了丙咪嗪抗室早的有效剂量和血浆浓度范围。方法:15例心脏病患者,室甲均>30次/小时,每日服丙咪嗪1毫克/公斤,分2次服,12小时1次。剂量隔日增加1毫克/公斤,以减少80％以上室早为度,日剂量最高不超过5毫克/公斤,不出现副作用。达有效剂量2天后,分别于 Imipramine has been widely used as a tricyclic antidepressant for more than 20 years. Recently confirmed that the drug has anti-arrhythmic effect. This article reports the effective early dose and plasma concentration range of imipramine. Methods: 15 cases of heart disease, room A were> 30 times / hour, daily imipramine 1 mg / kg, 2 times service, 12 hours 1 time. Dosage increase 1 mg / kg every other day to reduce the room as early as 80%, daily dose of not more than 5 mg / kg, no side effects. The effective dose of 2 days, respectively