论文部分内容阅读
本文观察到原用国产猪胰岛素治疗的成年糖尿病病人在换用半合成人胰岛素6个月后,日平均胰岛素剂量减少(P=0.09),空腹及餐后2小时血糖较换药前低(P<0.05);对照组均无明显改变。用人胰岛素者约半数病人血清胰岛素抗体逐渐下降;对照组大多继续上升。低血糖反应发生率两组相当。结果表明,人胰岛素的临床效果优于国产猪胰岛素,此与前者的免疫原性较低有密切关系。
In this paper, we observed that the mean daily insulin dose decreased (P = 0.09) and the fasting and postprandial 2-hour postprandial blood glucose levels were lower in patients with adult diabetes treated with porcine insulin <0.05); no significant change in the control group. About half of human insulin patients with serum insulin antibody decreased gradually; most of the control group continued to rise. The incidence of hypoglycemia was comparable in both groups. The results show that the clinical effect of human insulin is better than domestic pig insulin, which has a close relationship with the lower immunogenicity of the former.