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目的 探讨原发性肝细胞癌肝动脉栓塞化疗 (TACE)联合13 1I 碘化油内放射治疗的疗效。方法 原发性肝细胞癌 68例 ,随机分为 2组进行治疗。A组 (TACE组 ) :经导管肝动脉栓塞化疗 ,3 4例 ;B组 (联合治疗组 ) :肝动脉栓塞化疗联合13 1I 碘化油内放射治疗 ,3 4例。结果 TACE组二期手术切除率 8.8% ,组织学检查切除病灶的完全坏死率为 0 ,患者 1、2、3年生存率分别为64 .3 %、3 9.3 %和 2 1.4%。联合治疗组二期手术切除率 2 9.4% ,切除病灶完全坏死率为 76.9% ,1、2、3年生存率分别为 96.4%、82 .1%和 60 .7%。 2组 1、2、3年生存率、二期手术切除率和肿瘤坏死率相比较 ,均有显著性差异 (P <0 .0 5 )。结论 TACE联合13 1I 碘化油内放射治疗效果优于单纯栓塞化疗。
Objective To investigate the efficacy of transcatheter hepatic arterial chemoembolization (TACE) in combination with 131I iodinated oil internal radiation therapy. Methods 68 cases of primary hepatocellular carcinoma were randomly divided into two groups for treatment. A group (TACE group): transcatheter hepatic arterial chemoembolization, 34 cases; B group (combination therapy group): hepatic arterial chemoembolization combined with 131I iodinated oil in the radiotherapy, 34 cases. Results The second stage of surgical resection rate was 8.8% in TACE group, and the complete necrosis rate was 0 in histological examination. The 1, 2, 3 year survival rates were 64.3%, 9.33% and 2.14% respectively. In the combined treatment group, the second stage of surgical resection rate was 2 9.4%, the complete necrosis rate of resected lesions was 76.9%, and the 1, 2, 3-year survival rates were 96.4%, 82.1% and 60.7%, respectively. The 1, 2, 3-year survival rates, stage II resection rates and tumor necrosis rates in two groups were significantly different (P <0.05). Conclusion TACE combined with 13I I iodized oil radiotherapy is better than simple embolization chemotherapy.