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目的：建立非放射性彩色微球测定穿壁及分层单位心肌血流量的方法并检测其准确性。方法：应用非放射性彩色微球测定２０只猪冠状动脉狭窄前后穿壁及分层单位心肌血流量，并与超声血流计测值比较。结果：穿壁单位心肌血流量超声血流计与非放射性彩色微球测值呈高度线性相关（ｙ＝０．８２２ｘ＋０．１４３，ｒ＝０．９６３，Ｐ＜０．００１）；不同颜色非放射性彩色微球对同一时刻单位心肌血流量测值无显著差异（Ｐ＞０．０５）；非放射性彩色微球在冠状动脉狭窄前测得心内膜、心外膜下单位心肌血流量分别为１．４３±０．５３和１．２８±０．５４ｍｌ／（ｇｍｉｎ）（Ｐ＜０．０１）；狭窄后分别为０．６７±０．３１和０．８８±０．３２ｍｌ／（ｇｍｉｎ）（Ｐ＜０．０１）。狭窄后心内膜下比心外膜下单位心肌血流量下降幅度更为显著（Ｐ＜０．０１）。结论：非放射性彩色微球可准确测定穿壁及分层单位心肌血流量，可作为研究心肌灌注的一种新方法。
Objective: To establish a method of non-radioactive color microspheres for determination of myocardial blood flow through the wall and stratified units and test its accuracy. Methods: The myocardial perfusion and stratified myocardial blood flow before and after coronary stenosis were measured by non-radioactive color microspheres and compared with the ultrasonic flowmeter. Results: There was a highly linear correlation between myocardial blood flow ultrasonic hemodiltymeter and non-radioactive color microspheres (y = 0.822x + 0.143, r = 0.963, P <0.001) Color microspheres had no significant difference in myocardial flow measurement at the same time (P> 0.05). Non-radioactive color microspheres measured endocardium before coronary artery stenosis. The myocardial subcardiac myocardial blood flow were 1.43 ± 0.53 and 1.28 ± 0.54ml / (gmin), respectively (P <0.01); 0.67 ± 0.31 and 0.88 ± 0.32ml / (gmin) after stenosis (P <0.01). The decrease of myocardial blood flow was more significant in subendocardial than in subendocardial after stenosis (P <0.01). Conclusion: Non-radioactive colored microspheres can accurately measure the myocardial blood flow through the wall and stratified units, which can be used as a new method to study myocardial perfusion.