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目的探讨ABO新生儿溶血病的干预价值。方法对夫妇ABO血型不合1 341例孕妇进行血清抗体效价监测,对抗体效价>1∶128者进行药物治疗,并监测抗体效价,未接受治疗者作为对照组,比较两组新生儿ABO溶血病发生情况。结果 1 341例孕妇中筛查阳性946例,阳性率70.54%。792例孕妇接受治疗,治疗有效率为78.16%,ABO新生溶血发生率为55.56%,对照组发生率为76.62%,2组间发生率比较差异有统计学意义(χ2=23.64,P<0.01)。结论南宁地区新生ABO溶血病发生率较高,通过孕期IgG抗A(B)效价筛查,对高风险人群进行预防性干预可有效地降低新生ABO溶血病的发生。
Objective To investigate the intervention value of neonatal hemolytic disease in ABO. Methods The serum antibody titers of 1 341 pregnant women with ABO incompatibility in the couple were monitored, and the antibody titers> 1:128 were used for drug treatment. The antibody titers were monitored, and those who did not receive treatment were compared as control group. The ABO Hemolytic disease occurs. Results Among 1 341 pregnant women, 946 were positive for screening, the positive rate was 70.54%. 792 pregnant women received treatment, the effective rate was 78.16%, ABO hemolysis rate was 55.56%, the control group was 76.62%, the incidence of the two groups was significantly different (χ2 = 23.64, P <0.01) . Conclusions The incidence of neonatal ABO hemolytic disease is high in Nanning. Through preventive IgG (anti-A) screening during pregnancy, prophylactic intervention in high-risk groups can effectively reduce the incidence of neonatal ABO hemolytic disease.