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目的:探讨甲泼尼龙联合人血清蛋白对病毒性脑炎患儿血清及脑脊液中SP-D和Gal-9的影响。方法:选择2014年3月至2015年2月在我院治疗的病毒性患儿148例,根据随机数字表分为对照组和观察组,每组74例。对所有患儿进行基础治疗和更昔洛韦抗病毒治疗,对照组患儿采用甲泼尼龙静脉滴注,观察组患儿采用甲泼尼龙联合人血清蛋白进行治疗。对两组患儿临床疗效、血清及脑脊液SP-D和Gal-9水平进行评价和测定。结果:治疗前两组患儿的各指标均无统计学差异(P>0.05)。2个疗程后两组患儿的巴氏指数均显著提高(P<0.05),且观察组显著高于对照组(P<0.05);观察组患儿住院时间、退热时间和止吐时间均显著短于对照组(P<0.05);观察组和对照组的有效率分别为93.24%、81.08%,差异有统计学意义(P<0.05);两组患儿血清和脑脊液中SP-D水平均显著升高(P<0.05),且观察组显著高于对照组(P<0.05);两组患儿血清和脑脊液Ga1-9水平均显著降低(P<0.05),且观察组显著低于对照组(P<0.05);两组患儿的临床不良反应皆轻微且无显著差异(P>0.05)。结论:甲泼尼龙和人血清蛋白联合使用能有效治疗病毒性脑炎患儿,具有较高的临床推广价值。
Objective: To investigate the effect of methylprednisolone combined with human serum albumin on serum and cerebrospinal fluid levels of SP-D and Gal-9 in children with viral encephalitis. Methods: A total of 148 cases of viral hepatitis treated in our hospital from March 2014 to February 2015 were divided into control group and observation group according to random number table, with 74 cases in each group. All children with basic treatment and antiviral treatment of ganciclovir, control children with methylprednisolone intravenous infusion, the observation group of children treated with methylprednisolone combined with human serum protein. The clinical efficacy, serum and CSF SP-D and Gal-9 levels in both groups were evaluated and measured. Results: There was no significant difference between the two groups before treatment (P> 0.05). After 2 courses of treatment, the Papanicum Index of both groups were significantly increased (P <0.05), and the observation group was significantly higher than the control group (P <0.05); the hospitalization time, antipyretic time and antiemetic time (P <0.05). The effective rates of the observation group and the control group were 93.24% and 81.08%, respectively, with significant difference (P <0.05). The levels of SP-D in the serum and cerebrospinal fluid of the two groups were significantly higher than those in the control group (P <0.05), and the observation group was significantly higher than that of the control group (P <0.05). Ga1-9 levels in serum and cerebrospinal fluid in both groups were significantly decreased (P <0.05), and the observation group was significantly lower than (P <0.05). The clinical adverse reactions in both groups were mild and no significant difference (P> 0.05). Conclusion: The combination of methylprednisolone and human serum albumin can effectively treat children with viral encephalitis and has a high clinical value.