采用快速膜乳化法,以二氯甲烷为油相,通过溶剂挥发制孔,在室温下制备了一系列聚乙二醇聚乳酸共聚物(PELA)多孔微球.结果表明,优化的制备条件为:搅拌速度250r/min、油相中PELA浓度50g/L、水/二氯甲烷/PVA水溶液体积比1:2.5:25及mPEG:PLA分子量比1:14,在该条件下可制备粒径均一、尺寸可控的PELA多孔微球,且孔径较大,孔径最大为15.0nm,属介孔材料,可用于蛋白多肽类药物的吸附. A series of polyethylene glycol polylactic acid copolymer (PELA) porous microspheres were prepared at room temperature by a rapid membrane emulsification method using methylene chloride as the oil phase and solvent evaporation of the pores.The results showed that the optimized preparation conditions were : Stirring speed 250r / min, oil phase PELA concentration 50g / L, water / dichloromethane / PVA aqueous solution volume ratio of 1: 2.5: 25 and mPEG: PLA molecular weight ratio 1:14, under the conditions of uniform particle size can be prepared , Size controllable PELA porous microspheres, and a larger pore size, pore size up to 15.0nm, is a mesoporous material can be used for protein peptide drug adsorption.