【摘 要】
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Dear Editor,rnPotassium channels are integral membrane proteins that selectively conduct K+ ions across cell membrane (Hille, 2001). They play essential roles i
【机 构】
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Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, Unive
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Dear Editor,rnPotassium channels are integral membrane proteins that selectively conduct K+ ions across cell membrane (Hille, 2001). They play essential roles in maintaining cellular ionic homoeostasis and generating action membrane potentials in excitable cells. The mechanism of K+ selectivity has been evaluated in many biophysical and physiological studies (Zhou et al., 2001;Liu et al., 2015;Schewe et al., 2016). A highly conserved signature sequence, TVGYG, in the selectivity filter of potassium channels (e.g., KcsA) is known to coordinate K+ions (Zhou et al., 2001).
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