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因为利福平在水中几乎不溶,所以在许多配制利福平滴眼液的方法中,通常选用无水乙醇、碳酸氢钠 溶液或者磷酸二氢钠溶液等做溶剂,将利福平溶解后再加入溶媒中混合均匀。也可以加入甘油、吐温—80等助溶剂或增溶剂,促使利福平在溶媒中溶解。其中以加无水乙醇溶解利福平的方法用得最多。用这些方法配制利福平滴眼液时,有的需要研磨,有的需要长时间搅拌或振摇,配制时比较费时费力。
Because rifampicin is almost insoluble in water, in many methods of formulating rifampicin eye drops, it is usual to use anhydrous ethanol, sodium bicarbonate solution or sodium dihydrogen phosphate solution as a solvent to dissolve the rifampicin Join in the solvent and mix well. You can also add glycerol, Tween -80 and other cosolvents or solubilizers to promote rifampin dissolved in the solvent. Among them, the method of dissolving rifampicin by adding anhydrous ethanol is the most used. Rifampicin eye drops prepared by these methods, some need grinding, and some need long time to stir or shake, preparation time-consuming and laborious.