肠道菌群是人体的重要组成部分,并在肠易激综合征的发病过程中起到重要作用。近年来的研究表明,多种类型的微生态制剂能够对肠易激综合征起到治疗作用。文章总结了肠道菌群调节在肠易激综合征方面的循证医学证据,结合临床实践经验进行归纳,并提出肠道菌群干预应遵循“先破后立”的原则。 Intestinal flora is an important part of the body and plays an important role in the pathogenesis of irritable bowel syndrome. In recent years, research shows that many types of probiotics can play a therapeutic role in irritable bowel syndrome. The article summarizes evidence-based medical evidence of gut microbiota regulation in irritable bowel syndrome, and summarizes the experience of clinical practice. It is suggested that the intervention of intestinal flora should follow the principle of “break after the first break”.