采用原位免疫复体动物模型,按15mg/kg雷公藤多甙服用四周,尿蛋白明显下降,盘状蛋白电泳从大分子转向中分子蛋白,血浆蛋白、肌酐均恢复正常。病理检查示治疗组肾小球大小与细胞数均明显小于对照组,IgG,C3,BSA~+及带负电荷辣根过氧化酶在肾小球中沉积不明显。作者对雷公藤多甙作用机理作了讨论。 Using an in situ immunological animal model, taking 15 mg/kg of tripterygium wilfordii for four weeks, urinary protein was significantly decreased, and discoid protein electrophoresis shifted from macromolecules to mid-molecule proteins, and plasma protein and creatinine returned to normal. Pathological examination showed that the size of the glomerulus and the number of cells in the treatment group were significantly smaller than those in the control group. IgG, C3, BSA~+, and negatively charged horseradish peroxidase were not significantly deposited in the glomerulus. The authors discuss the mechanism of multi-quinone action of Tripterygium wilfordii.