论文部分内容阅读
目的:探讨MMP-2、TIMP-2和CD44V6的表达与卵巢浆液性肿瘤侵袭和转移的关系。方法:应用流式细胞免疫法定量检测MMP-2、TIMP-2和CD44V6在45例卵巢浆液性肿瘤中的表达。结果:MMP-2、TIMP-2和CD44V6在卵巢浆液性癌中的表达明显高于卵巢浆液性瘤(P<0.05),且与卵巢浆液性癌组织分级和临床分期密切相关(P<0.05)。MMP-2和TIMP-2、MMP-2和CD44V6在卵巢浆液性癌中的表达密切相关(P<0.05)。结论:卵巢浆液性癌中MMP-2、TIMP-2和CD44V6的高表达促进了癌的侵袭和转移,MMP-2和TIMP-2、MMP-2和CD44V6在卵巢浆液性癌中的表达有相关性。提示MMP-2、TIMP-2和CD44V6的共同检测可作为疾病诊断和判断预后的参考指标。
Objective: To investigate the relationship between the expression of MMP-2, TIMP-2 and CD44V6 and the invasion and metastasis of ovarian serous tumors. Methods: Flow cytometry was used to detect the expression of MMP-2, TIMP-2 and CD44V6 in 45 cases of ovarian serous tumors. Results: The expressions of MMP-2, TIMP-2 and CD44V6 in ovarian serous carcinoma were significantly higher than those in ovarian serous carcinoma (P <0.05), and were closely related to the grade and clinical stage of ovarian serous carcinoma (P <0.05) . The expression of MMP-2 and TIMP-2, MMP-2 and CD44V6 in ovarian serous carcinoma was closely related (P <0.05). CONCLUSIONS: The overexpression of MMP-2, TIMP-2 and CD44V6 in ovarian serous carcinomas can promote the invasion and metastasis of cancer. The expressions of MMP-2, TIMP-2, MMP-2 and CD44V6 in ovarian serous carcinoma are correlated Sex. Tip MMP-2, TIMP-2 and CD44V6 common detection can be used as a disease diagnosis and prognosis of reference indicators.