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目的 对胃癌患者实施肿瘤浸润淋巴细胞(TIL)免疫治疗。 方法 培养收获TIL细胞,并回输患者。 结果 TIL治疗能使部分患者瘤体缩小,生存期延长,一般症状显著改善。治疗前后免疫学参数(CD3/CD4,自体LAK 活性,血清SIL-2R水平)表明,TIL治疗可以提高患者机体免疫功能,增强抗癌抑癌能力。 结论 对胃癌患者综合治疗,TIL免疫治疗值得临床进一步扩大应用。
Objective To perform tumor-infiltrating lymphocyte (TIL) immunotherapy for gastric cancer patients. Methods TIL cells were harvested and returned to patients. Results TIL therapy can reduce the tumor size, prolong the survival time, and generally improve the symptoms of some patients. Before and after treatment, immunological parameters (CD3/CD4, autologous LAK activity, and serum SIL-2R levels) showed that TIL therapy can improve the body’s immune function and enhance the anti-cancer and cancer suppressing ability. Conclusion For comprehensive treatment of gastric cancer, TIL immunotherapy is worthy of further clinical application.